Caltech Logo
Sternberg Lab

Our laboratory is interested in the systems biology of nematodes. We seek to understand how the properties of an organism are encoded in its genome.

We seek to understand how are the properties of an organism – its development, physiology and behavior – are encoded in its genome. We primarily use molecular genetics of the nematode Caenorhabditis elegans but also apply proteomics, computational biology, biochemistry, cell biology, imaging, behavioral analysis, optogenetics, synthetic biology to not only C. elegans but also parasitic nematodes, budding yeast, mice, jellyfish, fungi, and human cells as needed.

腾讯网游加速器软件下载-安卓版腾讯网游加速器app免费下载 ...:2021-6-15 · 腾讯网游加速器软件特征 1.独享专线低推迟 独享金融级专线，腾讯国内外尖端IDC机房 极致加快，离别推迟 2.智能节点超安稳 智能线路挑选，腾讯独家优化计划 全天候保证您的链接安稳 3.全球掩盖超速度 全球5大洲机房，800+节点布置 加快作用更好，兼容更广

  • How does the 302-neuron worm brain assess the future environment based on computation of sensory and physiological inputs?
  • Does the male worm have a neural representation of its mating partner?
  • How can we best predict gene expression from DNA sequence?
  • 《Valorant》公测火爆 UU加速器让你告别卡顿统治战场_游侠 ...:2021-6-8 · 网易UU加速器搭载网易自研专利内核，全球铺设多个外网直连节点，大幅度降低网络延迟，轻松解决外网环境问题。玩家们不用担心让人抓狂的掉线问题，与敌人钢枪酣战时，摆脱高延时的困扰，UU加速器会带给你最流畅的游戏体验。
  • What changes in the nervous system occur during sleep?
  • How do cells migrate accurately during development?

Our major strategy is to perturb the activity of one or more genes and measure how cells or animals misbehave to infer gene function and genetic pathways. We measure gene expression by RNA-seq and transgenic reporters; we measure behavior using automated systems and optogenetics. We focus on intercellular signals and their transduction by the responding cell into transcriptional outputs. Many of the genes we have identified are the nematode counterparts of human genes, and we are leveraging C. elegansmolecular genetics to study human genes with no actionable information and of the consequence of variants found in human individuals, including those with autism spectrum disorder. Nematodes are major health and agricultural problems, so we focus on parasite relevant biology such as dauer/infective juvenile development, using genomics and molecular genetics.

布谷加速器 干嘛用的

An exciting article about our newest Molecular Cell paper is currently available here.

Our peer-reviewed, single-result publication platform microPublication Biology is now included in PubMedCentral and indexed in PubMed. The Caltech Library is the publisher. This is the first biology journal designed to help get information into knowledge such as WormBase, ZFIN, SGD, 免费全球节点加速器, and TAIR.

Undergraduate Student Sophie Walton has been awarded a Hertz Fellowship. Click here to read all about her amazing accomplishment.

May 15, 2020. Porfirio Quintero Cadena defended his thesis "Mechanism and Scaling of Eukaryotic Transcription Activaton". Congratulations, Porfirio!

May 11, 2020. Katherine Brugman defended her thesis "pezo-1 function in Caenorhabditis elegans". Great work, Katie!

Our newest paper about Mono Lake worms in out now. Click on the following links to read all about it:

http://www.caltech.edu/about/news/otherworldly-worms-three-sexes-discovered-mono-lake.

http://www.the-scientist.com/news-opinion/arsenic-resistant-nematodes-found-in-mono-lake-66493

We are proud to announce Dr. Han Wang will start his own lab at the University of Wisconsin, Madison in January 2020. He will be a part of the 全球加速联动WAF和GTM实现企业ERP应用加速 - 最佳实践 ...:2021-6-10 · 全球加速联动Web应用防火墙（WAF）和全局流量管理（GTM）实现企业ERP管理系统加速，基于云安全大数据能力，同时依托阿里巴巴优质BGP带宽和全球传输网络，实现全球网络就近接入和跨地域部署，为企业ERP管理系统提供一套高安全的跨地域 .... You can learn more about his new lab at www.hanwanglab.com.

  1. Quintero-Cadena P, Lenstra TL, Sternberg PW. (2020). RNA pol II length and disorder enable cooperative scaling of transcriptional bursting. Mol Cel [epub ahead of print]. doi: 10.1016/j.molcel.2020.5.030.
  2. Walton SJ, Wang H, Quintero-Cadena P, Bateman A, Sternberg PW. (2020). Caenorhabditis elegans AF4/FMR2 family homolog affl-2 regulates heat shock induced gene expression. Genetics. [epub ahead of print]. doi: 10.1534/genetics.120.302923.
  3. Bai X, Bouffard JW, Lord A, Brugman K, Sternberg PW, Cram EJ, Golden A. (2020). Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation. Elife. [epub ahead of print]. doi: 10.7554/eLife.53603.
  4. Arnaboldi V, Raciti D, Van Auken K, Chan JN, Müller HM, Sternberg PW. (2020). Text mining meets community curation: a newly designed curation platform to improve author experience at WormBase. Database (Oxford). [epub ahead of print] doi: 1093/database/baaa006. PMCID: PMC7078066.
  5. 腾讯网游加速器软件下载-安卓版腾讯网游加速器app免费下载 ...:2021-6-15 · 腾讯网游加速器软件特征 1.独享专线低推迟 独享金融级专线，腾讯国内外尖端IDC机房 极致加快，离别推迟 2.智能节点超安稳 智能线路挑选，腾讯独家优化计划 全天候保证您的链接安稳 3.全球掩盖超速度 全球5大洲机房，800+节点布置 加快作用更好，兼容更广

  1. Cho J, Gao S, Stein L, Sternberg PW. (2020). Vennter – An interactive analysis tool for WormBase interaction data using Venn diagrams. microPublication Biology. 10.17912/micropub.biology.000258.